Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells.
Identifieur interne : 000492 ( Main/Exploration ); précédent : 000491; suivant : 000493Follistatin-like protein 1 regulates chondrocyte proliferation and chondrogenic differentiation of mesenchymal stem cells.
Auteurs : Yury Chaly [États-Unis] ; Harry C. Blair [États-Unis] ; Sonja M. Smith [États-Unis] ; Daniel S. Bushnell [États-Unis] ; Anthony D. Marinov [États-Unis] ; Brian T. Campfield [États-Unis] ; Raphael Hirsch [États-Unis]Source :
- Annals of the rheumatic diseases [ 1468-2060 ] ; 2015.
Descripteurs français
- KwdFr :
- Animaux, Cellules cultivées, Cellules stromales mésenchymateuses (), Cellules stromales mésenchymateuses (cytologie), Cellules stromales mésenchymateuses (physiologie), Chondrocytes (), Chondrocytes (cytologie), Chondrocytes (physiologie), Chondrogenèse (physiologie), Collagène de type II (métabolisme), Différenciation cellulaire (physiologie), Facteur de croissance transformant bêta (pharmacologie), Matrice extracellulaire (métabolisme), Modèles animaux, Prolifération cellulaire (physiologie), Protéines apparentées à la follistatine (déficit), Protéines apparentées à la follistatine (génétique), Protéines apparentées à la follistatine (physiologie), Protéoglycanes (métabolisme), Souris, Souris knockout, Transduction du signal ().
- MESH :
- cytologie : Cellules stromales mésenchymateuses, Chondrocytes.
- déficit : Protéines apparentées à la follistatine.
- génétique : Protéines apparentées à la follistatine.
- métabolisme : Collagène de type II, Matrice extracellulaire, Protéoglycanes.
- pharmacologie : Facteur de croissance transformant bêta.
- physiologie : Cellules stromales mésenchymateuses, Chondrocytes, Chondrogenèse, Différenciation cellulaire, Prolifération cellulaire, Protéines apparentées à la follistatine.
- Animaux, Cellules cultivées, Cellules stromales mésenchymateuses, Chondrocytes, Modèles animaux, Souris, Souris knockout, Transduction du signal.
English descriptors
- KwdEn :
- Animals, Cell Differentiation (physiology), Cell Proliferation (physiology), Cells, Cultured, Chondrocytes (cytology), Chondrocytes (drug effects), Chondrocytes (physiology), Chondrogenesis (physiology), Collagen Type II (metabolism), Extracellular Matrix (metabolism), Follistatin-Related Proteins (deficiency), Follistatin-Related Proteins (genetics), Follistatin-Related Proteins (physiology), Mesenchymal Stromal Cells (cytology), Mesenchymal Stromal Cells (drug effects), Mesenchymal Stromal Cells (physiology), Mice, Mice, Knockout, Models, Animal, Proteoglycans (metabolism), Signal Transduction (drug effects), Transforming Growth Factor beta (pharmacology).
- MESH :
- chemical , deficiency : Follistatin-Related Proteins.
- chemical , genetics : Follistatin-Related Proteins.
- chemical , metabolism : Collagen Type II, Proteoglycans.
- cytology : Chondrocytes, Mesenchymal Stromal Cells.
- drug effects : Chondrocytes, Mesenchymal Stromal Cells, Signal Transduction.
- metabolism : Extracellular Matrix.
- chemical , pharmacology : Transforming Growth Factor beta.
- physiology : Cell Differentiation, Cell Proliferation, Chondrocytes, Chondrogenesis, Follistatin-Related Proteins, Mesenchymal Stromal Cells.
- Animals, Cells, Cultured, Mice, Mice, Knockout, Models, Animal.
Abstract
Chondrocytes, the only cells in the articular cartilage, play a pivotal role in osteoarthritis (OA) because they are responsible for maintenance of the extracellular matrix (ECM). Follistatin-like protein 1 (FSTL1) is a secreted protein found in mesenchymal stem cells (MSCs) and cartilage but whose function is unclear. FSTL1 has been shown to modify cell growth and survival. In this work, we sought to determine whether FSTL1 could regulate chondrogenesis and chondrogenic differentiation of MSCs.
DOI: 10.1136/annrheumdis-2013-204822
PubMed: 24641944
Affiliations:
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Le document en format XML
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Blair</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA VA Medical Center, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA VA Medical Center, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Smith, Sonja M" sort="Smith, Sonja M" uniqKey="Smith S" first="Sonja M" last="Smith">Sonja M. Smith</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author><author><name sortKey="Bushnell, Daniel S" sort="Bushnell, Daniel S" uniqKey="Bushnell D" first="Daniel S" last="Bushnell">Daniel S. Bushnell</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Marinov, Anthony D" sort="Marinov, Anthony D" uniqKey="Marinov A" first="Anthony D" last="Marinov">Anthony D. Marinov</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Campfield, Brian T" sort="Campfield, Brian T" uniqKey="Campfield B" first="Brian T" last="Campfield">Brian T. Campfield</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Hirsch, Raphael" sort="Hirsch, Raphael" uniqKey="Hirsch R" first="Raphael" last="Hirsch">Raphael Hirsch</name><affiliation wicri:level="2"><nlm:affiliation>Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pediatrics, University of Iowa Carver College of Medicine, Iowa City, Iowa</wicri:regionArea><placeName><region type="state">Iowa</region></placeName></affiliation></author></analytic><series><title level="j">Annals of the rheumatic diseases</title><idno type="eISSN">1468-2060</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Cell Differentiation (physiology)</term><term>Cell Proliferation (physiology)</term><term>Cells, Cultured</term><term>Chondrocytes (cytology)</term><term>Chondrocytes (drug effects)</term><term>Chondrocytes (physiology)</term><term>Chondrogenesis (physiology)</term><term>Collagen Type II (metabolism)</term><term>Extracellular Matrix (metabolism)</term><term>Follistatin-Related Proteins (deficiency)</term><term>Follistatin-Related Proteins (genetics)</term><term>Follistatin-Related Proteins (physiology)</term><term>Mesenchymal Stromal Cells (cytology)</term><term>Mesenchymal Stromal Cells (drug effects)</term><term>Mesenchymal Stromal Cells (physiology)</term><term>Mice</term><term>Mice, Knockout</term><term>Models, Animal</term><term>Proteoglycans (metabolism)</term><term>Signal Transduction (drug effects)</term><term>Transforming Growth Factor beta (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules stromales mésenchymateuses ()</term><term>Cellules stromales mésenchymateuses (cytologie)</term><term>Cellules stromales mésenchymateuses (physiologie)</term><term>Chondrocytes ()</term><term>Chondrocytes (cytologie)</term><term>Chondrocytes (physiologie)</term><term>Chondrogenèse (physiologie)</term><term>Collagène de type II (métabolisme)</term><term>Différenciation cellulaire (physiologie)</term><term>Facteur de croissance transformant bêta (pharmacologie)</term><term>Matrice extracellulaire (métabolisme)</term><term>Modèles animaux</term><term>Prolifération cellulaire (physiologie)</term><term>Protéines apparentées à la follistatine (déficit)</term><term>Protéines apparentées à la follistatine (génétique)</term><term>Protéines apparentées à la follistatine (physiologie)</term><term>Protéoglycanes (métabolisme)</term><term>Souris</term><term>Souris knockout</term><term>Transduction du signal ()</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Follistatin-Related Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Follistatin-Related Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Collagen Type II</term><term>Proteoglycans</term></keywords><keywords scheme="MESH" qualifier="cytologie" xml:lang="fr"><term>Cellules stromales mésenchymateuses</term><term>Chondrocytes</term></keywords><keywords scheme="MESH" qualifier="cytology" xml:lang="en"><term>Chondrocytes</term><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Chondrocytes</term><term>Mesenchymal Stromal Cells</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="déficit" xml:lang="fr"><term>Protéines apparentées à la follistatine</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines apparentées à la follistatine</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Extracellular Matrix</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Collagène de type II</term><term>Matrice extracellulaire</term><term>Protéoglycanes</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Facteur de croissance transformant bêta</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Transforming Growth Factor beta</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Cellules stromales mésenchymateuses</term><term>Chondrocytes</term><term>Chondrogenèse</term><term>Différenciation cellulaire</term><term>Prolifération cellulaire</term><term>Protéines apparentées à la follistatine</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Cell Differentiation</term><term>Cell Proliferation</term><term>Chondrocytes</term><term>Chondrogenesis</term><term>Follistatin-Related Proteins</term><term>Mesenchymal Stromal Cells</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Mice</term><term>Mice, Knockout</term><term>Models, Animal</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Cellules cultivées</term><term>Cellules stromales mésenchymateuses</term><term>Chondrocytes</term><term>Modèles animaux</term><term>Souris</term><term>Souris knockout</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Chondrocytes, the only cells in the articular cartilage, play a pivotal role in osteoarthritis (OA) because they are responsible for maintenance of the extracellular matrix (ECM). Follistatin-like protein 1 (FSTL1) is a secreted protein found in mesenchymal stem cells (MSCs) and cartilage but whose function is unclear. FSTL1 has been shown to modify cell growth and survival. In this work, we sought to determine whether FSTL1 could regulate chondrogenesis and chondrogenic differentiation of MSCs.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Iowa</li><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Iowa"><name sortKey="Chaly, Yury" sort="Chaly, Yury" uniqKey="Chaly Y" first="Yury" last="Chaly">Yury Chaly</name></region><name sortKey="Blair, Harry C" sort="Blair, Harry C" uniqKey="Blair H" first="Harry C" last="Blair">Harry C. Blair</name><name sortKey="Bushnell, Daniel S" sort="Bushnell, Daniel S" uniqKey="Bushnell D" first="Daniel S" last="Bushnell">Daniel S. Bushnell</name><name sortKey="Campfield, Brian T" sort="Campfield, Brian T" uniqKey="Campfield B" first="Brian T" last="Campfield">Brian T. Campfield</name><name sortKey="Hirsch, Raphael" sort="Hirsch, Raphael" uniqKey="Hirsch R" first="Raphael" last="Hirsch">Raphael Hirsch</name><name sortKey="Marinov, Anthony D" sort="Marinov, Anthony D" uniqKey="Marinov A" first="Anthony D" last="Marinov">Anthony D. Marinov</name><name sortKey="Smith, Sonja M" sort="Smith, Sonja M" uniqKey="Smith S" first="Sonja M" last="Smith">Sonja M. Smith</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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